Milan were gunning for an opening win of the season last time out before their defence faltered and allowed Napoli to come from 2-1 down and secure a 3-2 win over them.
That result was a major setback that has sent their manager back to the drawing board.
The former European champions are looking to get back into the Champions League this season and they made some of the best transfer deals this summer, so this game is another chance for them to show that they are ready to bounce back.
One problem Milan had against Napoli was that their defenders were not confident enough to play from the back despite that being their preferred style and that could be their undoing here as well if they do not patch that issue.
AS Roma had to come back from the dead to save themselves from an embarrassing home defeat last time out.
The Rome-based side were 3-1 down to Atalanta before fighting back to share the points.
Roma come into this game unbeaten in their last two games into the new season and they will be looking to press Milan here thanks to the blueprint left by Napoli last weekend.
This is going to be a tough game for Milan as they have won just two of 12 games against the top seven sides in the last campaign, however, they can take that as a challenge and prove that they are ready to be back among the elites again.
This is one of the more competitive and interesting games of the weekend in Serie A and bookmakers make Milan slight favourites at home.
There is no doubt Roma will have their supporters and the odds suggest there will be goals in this game with over 2.5 goals currently trading at odds-on.
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