Juventus have made a solid return from tough times that included being relegated to the second division a number of years back to win the last 6 Italian league titles.
After signing Cristiano Ronaldo in the summer, they have their eyes set on winning the Champions League, but they will also not want another side to take away their Italian crown.
This game should be one of the biggest tests they face in retaining the Scudetto this season.
Juventus come into this game in fine form. They have an 8 points gap over Napoli at the top of the league table and the only time they have been beaten in any competition this season was against Manchester United in the Champions League.
Juventus have won 4 consecutive games since that defeat at the hands of Manchester United and they will want Inter Milan to be their next casualty.
Inter Milan finally made a return to the Champions League this season and they are looking to make that a yearly occurrence.
They have been in fine form in Europe and need a win against PSV in their final group game to progress to the knockout stages.
However, their local form has suffered a dip recently as they have picked up just 4 points from their last 3 Serie A games.
Inter remain 3rd in the league table and they will be looking to inflict a first loss of the season on Juventus in this game.
This game appears to be extremely competitive on paper however bookmakers have priced Juventus up as strong odds-on favourites to get the job done at home.
Goal markets are undecided as to the number of goals we will see however Cristiano Ronaldo is clear favourite with bookies to score the first goal followed by Mario Mandzukic and Paulo Dybala.
This game gets underway at 19:30 BST.
Results of each team’s last 5 matches across all leagues and competitions
Football Previews
Please Gamble Responsibly