Celta have had an up and down season this time around but their impressive 1-3 away win over Deportivo last time out will have boosted their confidence ahead of the visit of Barcelona.
Last season, they impressively eliminated Real Madrid from this competition only to be knocked out by Alaves in the semifinal.
This game offers them another chance to enhance their reputation as giant killers.
In the last round, their manager tried a mixed line up as they defeated Eibar 3-1 over two legs but this game is too big for him not to field likes of Iago Aspas, Maxi Gomez and Pione Sisto.
Barcelona closed last year in impressive fashion with a win over bitter rivals Real Madrid away.
That victory helped them open a 14 points gap over Los Merenges and they will be looking to add the Copa Del Rey trophy to their cabinet this season.
They face a tough challenge against Celta Vigo here and they will definitely not be taking the risk of resting their star men here as Celta are not a team to be underrated.
Barcelona head into this game off the back of four consecutive clean sheets and that could see this game end in a low scoring affair.
Results of each team’s last 5 matches across all leagues and competitions