While most teams have struggled locally while playing in Europe, these two sides have done admirably so far with domestic and European commitments.
Lyon finished second in their group behind Atalanta and ahead of Everton while Villarreal finished top of a tough group which had only three points separating the top three.
Lyon have faced Spanish opposition in the past couple of seasons but this is their first encounter with Villarreal.
They have played over 30 games against opponents from La Liga, wining 9, losing 13, and drawing 8.
Villarreal head into this game off the back of four wins and two losses in their last six games, while Lyon have won three and lost three of their last six.
The Spanish visitors head into this game off the back of two consecutive league losses and Lyon would hoping to help them extend that miserable run of form.
Lyon’s trio of Traore, Fekir and Depay are a very potent attacking unit and they will be looking give Villarreal troubles.
Cedric Bakambu is Villarreal’s top scorer in Europe this season but he has since moved to the Chinese Super League.
They will be banking on Carlos Bacca to help them with the goals to win this game.
Results of each team’s last 5 matches across all leagues and competitions