There is trouble brewing at Old Trafford at the moment and it seems like the end is very close for Jose Mourinho. The result of this match is sure to have an impact on his future.
Manchester United slumped to a 3-1 defeat at the hands of West Ham at the weekend to make this their worst start to a league campaign since 1989.
They had been eliminated from the Carabao Cup at home to Derby County prior to that and drew to Wolves in their previous league.
They come into this game off the back of three games without a win.
The last time they won a game was in their Champions League opener against Young Boys however Valencia represent a significant step up in quality.
Valencia aren’t exactly on a hot streak of form at the moment, but they seem to gradually be coming into their best as the season progresses.
They beat Real Sociedad at the weekend to record their first win of the season, however, they have lost just two of their previous seven games, one of which was a 2-0 home loss to Juventus in the Champions League.
Valencia are one of the most organized teams defensively as they have been breached on just 8 occasions this season.
However, they are really struggling for goals at the moment as they have netted just 5 times all season so far.
Each of the last five competitive meetings between these sides have ended with fewer than three goals scored.
Bookmakers have priced Manchester United up as odds-on favourites to record their second Champions League win in as many games.
Results of each team’s last 5 matches across all leagues and competitions