Many observers believe they have overachieved by reaching this stage, but the Ugandans have nothing to lose and they will be keen to get their first win over Senegal in this game.
With the likes of Sadio Mane and Kalidou Koulibaly in their ranks, Senegal came into this competition as favourites, but they had to finish second in their group after losing to Algeria in one of their group games.
Senegal have one of the most exciting teams in this competition but there is a risk that they might not reach their potential and their performance in this game will go a long way to show how ready they are to go all the way.
The Senegalese have the best head-to-head record between these sides having won 2 and drawn 3 of the 5 times these sides have met.
Bookmakers have priced Senegal up as strong odds-on favourites to come out on top in this game while Uganda have a tough task ahead of them according to oddsmakers.
Goal markets point to an extremely tight game as under 2.5 goals is currently trading long odds-on while Sadio Mane is favourite to score the opening goal of the game.